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The Amplicon vector based-HAC is not integrated into the cellular genome

HSV amplicons are powerful vectors for efficient HAC cell lines production :

 

-  High efficiency of HAC transfer

-  Easy selection of HAC-cell clones

-  Stable maintenance of the HAC with or without drug

-  Constitutive and inducible promoters are available in the HAC

-  Strong or regulated gene expression can be obtained

Control cells do not express GFP or luciferase

DNA transfected cells express GFP and luciferase

The HAC-cell line strongly expresses luciferase but not GFP

A control cell line strongly expresses luciferase and GFP

Infection of the HAC-cell line with a RFP expressing Amplicon vector leads to the reactivation of GFP expression

 2 hpi                       24 hpi                       48 hpi

GFP

RFP

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Production of HAC cell lines

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